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Split gtsummary table by rows and/or columns

Source: R/tbl_split.R
tbl_split_by.Rd

[Experimental]
The tbl_split_by_rows() and tbl_split_by_columns() functions split a single gtsummary table into multiple tables. Both column-wise splitting (that is, splits by columns in x$table_body) and row-wise splitting is possible.

Usage

tbl_split_by_rows(
  x,
  variables = NULL,
  row_numbers = NULL,
  footnotes = c("all", "first", "last"),
  caption = c("all", "first", "last")
)

tbl_split_by_columns(
  x,
  keys,
  groups,
  footnotes = c("all", "first", "last"),
  caption = c("all", "first", "last")
)

# S3 method for class 'tbl_split'
print(x, ...)

Arguments

x

(gtsummary or list)
gtsummary table.

variables, row_numbers

(tidy-select or integer)
variables or row numbers at which to split the gtsummary table rows (tables will be separated after each of these variables).

footnotes, caption

(string) [Experimental]
can be either "first", "all", or "last", to locate global footnotes or caption only on the first, in each, or in the last table, respectively. It defaults to "all". Reference footnotes are always present wherever they appear.

keys

(tidy-select)
columns to be repeated in each table split. It defaults to the first column if missing (usually label column).

groups

(list of character vectors)
list of column names that appear in x$table_body. Each group of column names represent a different table in the output list.

...

These dots are for future extensions and must be empty.

Value

tbl_split object. If multiple splits are performed (e.g., both by row and columns), the output is returned a single level list.

Details

Run show_header_names() to print all column names to split by.

Footnotes and caption handling are experimental and may change in the future.

row_numbers indicates the row numbers at which to split the table. It means that the table will be split after each of these row numbers. If the last row is selected, the split will not happen as it is supposed to happen after the last row.

Examples

# Example 1 ----------------------------------
# Split by rows
trial |>
  tbl_summary(by = trt) |>
  tbl_split_by_rows(variables = c(marker, grade)) |>
  tail(n = 1) # Print only last table for simplicity
#> [[1]]
#> <div id="abpzdzuqzp" style="padding-left:0px;padding-right:0px;padding-top:10px;padding-bottom:10px;overflow-x:auto;overflow-y:auto;width:auto;height:auto;">
#>   <style>#abpzdzuqzp table {
#>   font-family: system-ui, 'Segoe UI', Roboto, Helvetica, Arial, sans-serif, 'Apple Color Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol', 'Noto Color Emoji';
#>   -webkit-font-smoothing: antialiased;
#>   -moz-osx-font-smoothing: grayscale;
#> }
#> 
#> #abpzdzuqzp thead, #abpzdzuqzp tbody, #abpzdzuqzp tfoot, #abpzdzuqzp tr, #abpzdzuqzp td, #abpzdzuqzp th {
#>   border-style: none;
#> }
#> 
#> #abpzdzuqzp p {
#>   margin: 0;
#>   padding: 0;
#> }
#> 
#> #abpzdzuqzp .gt_table {
#>   display: table;
#>   border-collapse: collapse;
#>   line-height: normal;
#>   margin-left: auto;
#>   margin-right: auto;
#>   color: #333333;
#>   font-size: 16px;
#>   font-weight: normal;
#>   font-style: normal;
#>   background-color: #FFFFFF;
#>   width: auto;
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #A8A8A8;
#>   border-right-style: none;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #A8A8A8;
#>   border-left-style: none;
#>   border-left-width: 2px;
#>   border-left-color: #D3D3D3;
#> }
#> 
#> #abpzdzuqzp .gt_caption {
#>   padding-top: 4px;
#>   padding-bottom: 4px;
#> }
#> 
#> #abpzdzuqzp .gt_title {
#>   color: #333333;
#>   font-size: 125%;
#>   font-weight: initial;
#>   padding-top: 4px;
#>   padding-bottom: 4px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-bottom-color: #FFFFFF;
#>   border-bottom-width: 0;
#> }
#> 
#> #abpzdzuqzp .gt_subtitle {
#>   color: #333333;
#>   font-size: 85%;
#>   font-weight: initial;
#>   padding-top: 3px;
#>   padding-bottom: 5px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-top-color: #FFFFFF;
#>   border-top-width: 0;
#> }
#> 
#> #abpzdzuqzp .gt_heading {
#>   background-color: #FFFFFF;
#>   text-align: center;
#>   border-bottom-color: #FFFFFF;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#> }
#> 
#> #abpzdzuqzp .gt_bottom_border {
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#> }
#> 
#> #abpzdzuqzp .gt_col_headings {
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#> }
#> 
#> #abpzdzuqzp .gt_col_heading {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: normal;
#>   text-transform: inherit;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#>   vertical-align: bottom;
#>   padding-top: 5px;
#>   padding-bottom: 6px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   overflow-x: hidden;
#> }
#> 
#> #abpzdzuqzp .gt_column_spanner_outer {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: normal;
#>   text-transform: inherit;
#>   padding-top: 0;
#>   padding-bottom: 0;
#>   padding-left: 4px;
#>   padding-right: 4px;
#> }
#> 
#> #abpzdzuqzp .gt_column_spanner_outer:first-child {
#>   padding-left: 0;
#> }
#> 
#> #abpzdzuqzp .gt_column_spanner_outer:last-child {
#>   padding-right: 0;
#> }
#> 
#> #abpzdzuqzp .gt_column_spanner {
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   vertical-align: bottom;
#>   padding-top: 5px;
#>   padding-bottom: 5px;
#>   overflow-x: hidden;
#>   display: inline-block;
#>   width: 100%;
#> }
#> 
#> #abpzdzuqzp .gt_spanner_row {
#>   border-bottom-style: hidden;
#> }
#> 
#> #abpzdzuqzp .gt_group_heading {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: initial;
#>   text-transform: inherit;
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#>   vertical-align: middle;
#>   text-align: left;
#> }
#> 
#> #abpzdzuqzp .gt_empty_group_heading {
#>   padding: 0.5px;
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: initial;
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   vertical-align: middle;
#> }
#> 
#> #abpzdzuqzp .gt_from_md > :first-child {
#>   margin-top: 0;
#> }
#> 
#> #abpzdzuqzp .gt_from_md > :last-child {
#>   margin-bottom: 0;
#> }
#> 
#> #abpzdzuqzp .gt_row {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   margin: 10px;
#>   border-top-style: solid;
#>   border-top-width: 1px;
#>   border-top-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#>   vertical-align: middle;
#>   overflow-x: hidden;
#> }
#> 
#> #abpzdzuqzp .gt_stub {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: initial;
#>   text-transform: inherit;
#>   border-right-style: solid;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #abpzdzuqzp .gt_stub_row_group {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: initial;
#>   text-transform: inherit;
#>   border-right-style: solid;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   vertical-align: top;
#> }
#> 
#> #abpzdzuqzp .gt_row_group_first td {
#>   border-top-width: 2px;
#> }
#> 
#> #abpzdzuqzp .gt_row_group_first th {
#>   border-top-width: 2px;
#> }
#> 
#> #abpzdzuqzp .gt_summary_row {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   text-transform: inherit;
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #abpzdzuqzp .gt_first_summary_row {
#>   border-top-style: solid;
#>   border-top-color: #D3D3D3;
#> }
#> 
#> #abpzdzuqzp .gt_first_summary_row.thick {
#>   border-top-width: 2px;
#> }
#> 
#> #abpzdzuqzp .gt_last_summary_row {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#> }
#> 
#> #abpzdzuqzp .gt_grand_summary_row {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   text-transform: inherit;
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #abpzdzuqzp .gt_first_grand_summary_row {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-top-style: double;
#>   border-top-width: 6px;
#>   border-top-color: #D3D3D3;
#> }
#> 
#> #abpzdzuqzp .gt_last_grand_summary_row_top {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-bottom-style: double;
#>   border-bottom-width: 6px;
#>   border-bottom-color: #D3D3D3;
#> }
#> 
#> #abpzdzuqzp .gt_striped {
#>   background-color: rgba(128, 128, 128, 0.05);
#> }
#> 
#> #abpzdzuqzp .gt_table_body {
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#> }
#> 
#> #abpzdzuqzp .gt_footnotes {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   border-bottom-style: none;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 2px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#> }
#> 
#> #abpzdzuqzp .gt_footnote {
#>   margin: 0px;
#>   font-size: 90%;
#>   padding-top: 4px;
#>   padding-bottom: 4px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #abpzdzuqzp .gt_sourcenotes {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   border-bottom-style: none;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 2px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#> }
#> 
#> #abpzdzuqzp .gt_sourcenote {
#>   font-size: 90%;
#>   padding-top: 4px;
#>   padding-bottom: 4px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #abpzdzuqzp .gt_left {
#>   text-align: left;
#> }
#> 
#> #abpzdzuqzp .gt_center {
#>   text-align: center;
#> }
#> 
#> #abpzdzuqzp .gt_right {
#>   text-align: right;
#>   font-variant-numeric: tabular-nums;
#> }
#> 
#> #abpzdzuqzp .gt_font_normal {
#>   font-weight: normal;
#> }
#> 
#> #abpzdzuqzp .gt_font_bold {
#>   font-weight: bold;
#> }
#> 
#> #abpzdzuqzp .gt_font_italic {
#>   font-style: italic;
#> }
#> 
#> #abpzdzuqzp .gt_super {
#>   font-size: 65%;
#> }
#> 
#> #abpzdzuqzp .gt_footnote_marks {
#>   font-size: 75%;
#>   vertical-align: 0.4em;
#>   position: initial;
#> }
#> 
#> #abpzdzuqzp .gt_asterisk {
#>   font-size: 100%;
#>   vertical-align: 0;
#> }
#> 
#> #abpzdzuqzp .gt_indent_1 {
#>   text-indent: 5px;
#> }
#> 
#> #abpzdzuqzp .gt_indent_2 {
#>   text-indent: 10px;
#> }
#> 
#> #abpzdzuqzp .gt_indent_3 {
#>   text-indent: 15px;
#> }
#> 
#> #abpzdzuqzp .gt_indent_4 {
#>   text-indent: 20px;
#> }
#> 
#> #abpzdzuqzp .gt_indent_5 {
#>   text-indent: 25px;
#> }
#> 
#> #abpzdzuqzp .katex-display {
#>   display: inline-flex !important;
#>   margin-bottom: 0.75em !important;
#> }
#> 
#> #abpzdzuqzp div.Reactable > div.rt-table > div.rt-thead > div.rt-tr.rt-tr-group-header > div.rt-th-group:after {
#>   height: 0px !important;
#> }
#> </style>
#>   <table class="gt_table" data-quarto-disable-processing="false" data-quarto-bootstrap="false">
#>   <thead>
#>     <tr class="gt_col_headings">
#>       <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="label"><span class='gt_from_md'><strong>Characteristic</strong></span></th>
#>       <th class="gt_col_heading gt_columns_bottom_border gt_center" rowspan="1" colspan="1" scope="col" id="stat_1"><span class='gt_from_md'><strong>Drug A</strong><br />
#> N = 98</span><span class="gt_footnote_marks" style="white-space:nowrap;font-style:italic;font-weight:normal;line-height:0;"><sup>1</sup></span></th>
#>       <th class="gt_col_heading gt_columns_bottom_border gt_center" rowspan="1" colspan="1" scope="col" id="stat_2"><span class='gt_from_md'><strong>Drug B</strong><br />
#> N = 102</span><span class="gt_footnote_marks" style="white-space:nowrap;font-style:italic;font-weight:normal;line-height:0;"><sup>1</sup></span></th>
#>     </tr>
#>   </thead>
#>   <tbody class="gt_table_body">
#>     <tr><td headers="label" class="gt_row gt_left">Tumor Response</td>
#> <td headers="stat_1" class="gt_row gt_center">28 (29%)</td>
#> <td headers="stat_2" class="gt_row gt_center">33 (34%)</td></tr>
#>     <tr><td headers="label" class="gt_row gt_left">    Unknown</td>
#> <td headers="stat_1" class="gt_row gt_center">3</td>
#> <td headers="stat_2" class="gt_row gt_center">4</td></tr>
#>     <tr><td headers="label" class="gt_row gt_left">Patient Died</td>
#> <td headers="stat_1" class="gt_row gt_center">52 (53%)</td>
#> <td headers="stat_2" class="gt_row gt_center">60 (59%)</td></tr>
#>     <tr><td headers="label" class="gt_row gt_left">Months to Death/Censor</td>
#> <td headers="stat_1" class="gt_row gt_center">23.5 (17.4, 24.0)</td>
#> <td headers="stat_2" class="gt_row gt_center">21.2 (14.5, 24.0)</td></tr>
#>   </tbody>
#>   
#>   <tfoot class="gt_footnotes">
#>     <tr>
#>       <td class="gt_footnote" colspan="3"><span class="gt_footnote_marks" style="white-space:nowrap;font-style:italic;font-weight:normal;line-height:0;"><sup>1</sup></span> <span class='gt_from_md'>Median (Q1, Q3); n (%)</span></td>
#>     </tr>
#>   </tfoot>
#> </table>
#> </div>
#> 

# Example 2 ----------------------------------
# Split by rows with row numbers
trial |>
  tbl_summary(by = trt) |>
  tbl_split_by_rows(row_numbers = c(5, 7)) |>
  tail(n = 1) # Print only last table for simplicity
#> [[1]]
#> <div id="zgsnwfndet" style="padding-left:0px;padding-right:0px;padding-top:10px;padding-bottom:10px;overflow-x:auto;overflow-y:auto;width:auto;height:auto;">
#>   <style>#zgsnwfndet table {
#>   font-family: system-ui, 'Segoe UI', Roboto, Helvetica, Arial, sans-serif, 'Apple Color Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol', 'Noto Color Emoji';
#>   -webkit-font-smoothing: antialiased;
#>   -moz-osx-font-smoothing: grayscale;
#> }
#> 
#> #zgsnwfndet thead, #zgsnwfndet tbody, #zgsnwfndet tfoot, #zgsnwfndet tr, #zgsnwfndet td, #zgsnwfndet th {
#>   border-style: none;
#> }
#> 
#> #zgsnwfndet p {
#>   margin: 0;
#>   padding: 0;
#> }
#> 
#> #zgsnwfndet .gt_table {
#>   display: table;
#>   border-collapse: collapse;
#>   line-height: normal;
#>   margin-left: auto;
#>   margin-right: auto;
#>   color: #333333;
#>   font-size: 16px;
#>   font-weight: normal;
#>   font-style: normal;
#>   background-color: #FFFFFF;
#>   width: auto;
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #A8A8A8;
#>   border-right-style: none;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #A8A8A8;
#>   border-left-style: none;
#>   border-left-width: 2px;
#>   border-left-color: #D3D3D3;
#> }
#> 
#> #zgsnwfndet .gt_caption {
#>   padding-top: 4px;
#>   padding-bottom: 4px;
#> }
#> 
#> #zgsnwfndet .gt_title {
#>   color: #333333;
#>   font-size: 125%;
#>   font-weight: initial;
#>   padding-top: 4px;
#>   padding-bottom: 4px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-bottom-color: #FFFFFF;
#>   border-bottom-width: 0;
#> }
#> 
#> #zgsnwfndet .gt_subtitle {
#>   color: #333333;
#>   font-size: 85%;
#>   font-weight: initial;
#>   padding-top: 3px;
#>   padding-bottom: 5px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-top-color: #FFFFFF;
#>   border-top-width: 0;
#> }
#> 
#> #zgsnwfndet .gt_heading {
#>   background-color: #FFFFFF;
#>   text-align: center;
#>   border-bottom-color: #FFFFFF;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#> }
#> 
#> #zgsnwfndet .gt_bottom_border {
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#> }
#> 
#> #zgsnwfndet .gt_col_headings {
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#> }
#> 
#> #zgsnwfndet .gt_col_heading {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: normal;
#>   text-transform: inherit;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#>   vertical-align: bottom;
#>   padding-top: 5px;
#>   padding-bottom: 6px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   overflow-x: hidden;
#> }
#> 
#> #zgsnwfndet .gt_column_spanner_outer {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: normal;
#>   text-transform: inherit;
#>   padding-top: 0;
#>   padding-bottom: 0;
#>   padding-left: 4px;
#>   padding-right: 4px;
#> }
#> 
#> #zgsnwfndet .gt_column_spanner_outer:first-child {
#>   padding-left: 0;
#> }
#> 
#> #zgsnwfndet .gt_column_spanner_outer:last-child {
#>   padding-right: 0;
#> }
#> 
#> #zgsnwfndet .gt_column_spanner {
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   vertical-align: bottom;
#>   padding-top: 5px;
#>   padding-bottom: 5px;
#>   overflow-x: hidden;
#>   display: inline-block;
#>   width: 100%;
#> }
#> 
#> #zgsnwfndet .gt_spanner_row {
#>   border-bottom-style: hidden;
#> }
#> 
#> #zgsnwfndet .gt_group_heading {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: initial;
#>   text-transform: inherit;
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#>   vertical-align: middle;
#>   text-align: left;
#> }
#> 
#> #zgsnwfndet .gt_empty_group_heading {
#>   padding: 0.5px;
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: initial;
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   vertical-align: middle;
#> }
#> 
#> #zgsnwfndet .gt_from_md > :first-child {
#>   margin-top: 0;
#> }
#> 
#> #zgsnwfndet .gt_from_md > :last-child {
#>   margin-bottom: 0;
#> }
#> 
#> #zgsnwfndet .gt_row {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   margin: 10px;
#>   border-top-style: solid;
#>   border-top-width: 1px;
#>   border-top-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#>   vertical-align: middle;
#>   overflow-x: hidden;
#> }
#> 
#> #zgsnwfndet .gt_stub {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: initial;
#>   text-transform: inherit;
#>   border-right-style: solid;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #zgsnwfndet .gt_stub_row_group {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: initial;
#>   text-transform: inherit;
#>   border-right-style: solid;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   vertical-align: top;
#> }
#> 
#> #zgsnwfndet .gt_row_group_first td {
#>   border-top-width: 2px;
#> }
#> 
#> #zgsnwfndet .gt_row_group_first th {
#>   border-top-width: 2px;
#> }
#> 
#> #zgsnwfndet .gt_summary_row {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   text-transform: inherit;
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #zgsnwfndet .gt_first_summary_row {
#>   border-top-style: solid;
#>   border-top-color: #D3D3D3;
#> }
#> 
#> #zgsnwfndet .gt_first_summary_row.thick {
#>   border-top-width: 2px;
#> }
#> 
#> #zgsnwfndet .gt_last_summary_row {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#> }
#> 
#> #zgsnwfndet .gt_grand_summary_row {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   text-transform: inherit;
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #zgsnwfndet .gt_first_grand_summary_row {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-top-style: double;
#>   border-top-width: 6px;
#>   border-top-color: #D3D3D3;
#> }
#> 
#> #zgsnwfndet .gt_last_grand_summary_row_top {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-bottom-style: double;
#>   border-bottom-width: 6px;
#>   border-bottom-color: #D3D3D3;
#> }
#> 
#> #zgsnwfndet .gt_striped {
#>   background-color: rgba(128, 128, 128, 0.05);
#> }
#> 
#> #zgsnwfndet .gt_table_body {
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#> }
#> 
#> #zgsnwfndet .gt_footnotes {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   border-bottom-style: none;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 2px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#> }
#> 
#> #zgsnwfndet .gt_footnote {
#>   margin: 0px;
#>   font-size: 90%;
#>   padding-top: 4px;
#>   padding-bottom: 4px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #zgsnwfndet .gt_sourcenotes {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   border-bottom-style: none;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 2px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#> }
#> 
#> #zgsnwfndet .gt_sourcenote {
#>   font-size: 90%;
#>   padding-top: 4px;
#>   padding-bottom: 4px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #zgsnwfndet .gt_left {
#>   text-align: left;
#> }
#> 
#> #zgsnwfndet .gt_center {
#>   text-align: center;
#> }
#> 
#> #zgsnwfndet .gt_right {
#>   text-align: right;
#>   font-variant-numeric: tabular-nums;
#> }
#> 
#> #zgsnwfndet .gt_font_normal {
#>   font-weight: normal;
#> }
#> 
#> #zgsnwfndet .gt_font_bold {
#>   font-weight: bold;
#> }
#> 
#> #zgsnwfndet .gt_font_italic {
#>   font-style: italic;
#> }
#> 
#> #zgsnwfndet .gt_super {
#>   font-size: 65%;
#> }
#> 
#> #zgsnwfndet .gt_footnote_marks {
#>   font-size: 75%;
#>   vertical-align: 0.4em;
#>   position: initial;
#> }
#> 
#> #zgsnwfndet .gt_asterisk {
#>   font-size: 100%;
#>   vertical-align: 0;
#> }
#> 
#> #zgsnwfndet .gt_indent_1 {
#>   text-indent: 5px;
#> }
#> 
#> #zgsnwfndet .gt_indent_2 {
#>   text-indent: 10px;
#> }
#> 
#> #zgsnwfndet .gt_indent_3 {
#>   text-indent: 15px;
#> }
#> 
#> #zgsnwfndet .gt_indent_4 {
#>   text-indent: 20px;
#> }
#> 
#> #zgsnwfndet .gt_indent_5 {
#>   text-indent: 25px;
#> }
#> 
#> #zgsnwfndet .katex-display {
#>   display: inline-flex !important;
#>   margin-bottom: 0.75em !important;
#> }
#> 
#> #zgsnwfndet div.Reactable > div.rt-table > div.rt-thead > div.rt-tr.rt-tr-group-header > div.rt-th-group:after {
#>   height: 0px !important;
#> }
#> </style>
#>   <table class="gt_table" data-quarto-disable-processing="false" data-quarto-bootstrap="false">
#>   <thead>
#>     <tr class="gt_col_headings">
#>       <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="label"><span class='gt_from_md'><strong>Characteristic</strong></span></th>
#>       <th class="gt_col_heading gt_columns_bottom_border gt_center" rowspan="1" colspan="1" scope="col" id="stat_1"><span class='gt_from_md'><strong>Drug A</strong><br />
#> N = 98</span><span class="gt_footnote_marks" style="white-space:nowrap;font-style:italic;font-weight:normal;line-height:0;"><sup>1</sup></span></th>
#>       <th class="gt_col_heading gt_columns_bottom_border gt_center" rowspan="1" colspan="1" scope="col" id="stat_2"><span class='gt_from_md'><strong>Drug B</strong><br />
#> N = 102</span><span class="gt_footnote_marks" style="white-space:nowrap;font-style:italic;font-weight:normal;line-height:0;"><sup>1</sup></span></th>
#>     </tr>
#>   </thead>
#>   <tbody class="gt_table_body">
#>     <tr><td headers="label" class="gt_row gt_left">    T3</td>
#> <td headers="stat_1" class="gt_row gt_center">22 (22%)</td>
#> <td headers="stat_2" class="gt_row gt_center">21 (21%)</td></tr>
#>     <tr><td headers="label" class="gt_row gt_left">    T4</td>
#> <td headers="stat_1" class="gt_row gt_center">23 (23%)</td>
#> <td headers="stat_2" class="gt_row gt_center">27 (26%)</td></tr>
#>     <tr><td headers="label" class="gt_row gt_left">Grade</td>
#> <td headers="stat_1" class="gt_row gt_center"><br /></td>
#> <td headers="stat_2" class="gt_row gt_center"><br /></td></tr>
#>     <tr><td headers="label" class="gt_row gt_left">    I</td>
#> <td headers="stat_1" class="gt_row gt_center">35 (36%)</td>
#> <td headers="stat_2" class="gt_row gt_center">33 (32%)</td></tr>
#>     <tr><td headers="label" class="gt_row gt_left">    II</td>
#> <td headers="stat_1" class="gt_row gt_center">32 (33%)</td>
#> <td headers="stat_2" class="gt_row gt_center">36 (35%)</td></tr>
#>     <tr><td headers="label" class="gt_row gt_left">    III</td>
#> <td headers="stat_1" class="gt_row gt_center">31 (32%)</td>
#> <td headers="stat_2" class="gt_row gt_center">33 (32%)</td></tr>
#>     <tr><td headers="label" class="gt_row gt_left">Tumor Response</td>
#> <td headers="stat_1" class="gt_row gt_center">28 (29%)</td>
#> <td headers="stat_2" class="gt_row gt_center">33 (34%)</td></tr>
#>     <tr><td headers="label" class="gt_row gt_left">    Unknown</td>
#> <td headers="stat_1" class="gt_row gt_center">3</td>
#> <td headers="stat_2" class="gt_row gt_center">4</td></tr>
#>     <tr><td headers="label" class="gt_row gt_left">Patient Died</td>
#> <td headers="stat_1" class="gt_row gt_center">52 (53%)</td>
#> <td headers="stat_2" class="gt_row gt_center">60 (59%)</td></tr>
#>     <tr><td headers="label" class="gt_row gt_left">Months to Death/Censor</td>
#> <td headers="stat_1" class="gt_row gt_center">23.5 (17.4, 24.0)</td>
#> <td headers="stat_2" class="gt_row gt_center">21.2 (14.5, 24.0)</td></tr>
#>   </tbody>
#>   
#>   <tfoot class="gt_footnotes">
#>     <tr>
#>       <td class="gt_footnote" colspan="3"><span class="gt_footnote_marks" style="white-space:nowrap;font-style:italic;font-weight:normal;line-height:0;"><sup>1</sup></span> <span class='gt_from_md'>Median (Q1, Q3); n (%)</span></td>
#>     </tr>
#>   </tfoot>
#> </table>
#> </div>
#> 

# Example 3 ----------------------------------
# Split by columns
trial |>
  tbl_summary(by = trt, include = c(death, ttdeath)) |>
  tbl_split_by_columns(groups = list("stat_1", "stat_2")) |>
  tail(n = 1) # Print only last table for simplicity
#> [[1]]
#> <div id="pvxtxlbnsl" style="padding-left:0px;padding-right:0px;padding-top:10px;padding-bottom:10px;overflow-x:auto;overflow-y:auto;width:auto;height:auto;">
#>   <style>#pvxtxlbnsl table {
#>   font-family: system-ui, 'Segoe UI', Roboto, Helvetica, Arial, sans-serif, 'Apple Color Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol', 'Noto Color Emoji';
#>   -webkit-font-smoothing: antialiased;
#>   -moz-osx-font-smoothing: grayscale;
#> }
#> 
#> #pvxtxlbnsl thead, #pvxtxlbnsl tbody, #pvxtxlbnsl tfoot, #pvxtxlbnsl tr, #pvxtxlbnsl td, #pvxtxlbnsl th {
#>   border-style: none;
#> }
#> 
#> #pvxtxlbnsl p {
#>   margin: 0;
#>   padding: 0;
#> }
#> 
#> #pvxtxlbnsl .gt_table {
#>   display: table;
#>   border-collapse: collapse;
#>   line-height: normal;
#>   margin-left: auto;
#>   margin-right: auto;
#>   color: #333333;
#>   font-size: 16px;
#>   font-weight: normal;
#>   font-style: normal;
#>   background-color: #FFFFFF;
#>   width: auto;
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #A8A8A8;
#>   border-right-style: none;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #A8A8A8;
#>   border-left-style: none;
#>   border-left-width: 2px;
#>   border-left-color: #D3D3D3;
#> }
#> 
#> #pvxtxlbnsl .gt_caption {
#>   padding-top: 4px;
#>   padding-bottom: 4px;
#> }
#> 
#> #pvxtxlbnsl .gt_title {
#>   color: #333333;
#>   font-size: 125%;
#>   font-weight: initial;
#>   padding-top: 4px;
#>   padding-bottom: 4px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-bottom-color: #FFFFFF;
#>   border-bottom-width: 0;
#> }
#> 
#> #pvxtxlbnsl .gt_subtitle {
#>   color: #333333;
#>   font-size: 85%;
#>   font-weight: initial;
#>   padding-top: 3px;
#>   padding-bottom: 5px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-top-color: #FFFFFF;
#>   border-top-width: 0;
#> }
#> 
#> #pvxtxlbnsl .gt_heading {
#>   background-color: #FFFFFF;
#>   text-align: center;
#>   border-bottom-color: #FFFFFF;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#> }
#> 
#> #pvxtxlbnsl .gt_bottom_border {
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#> }
#> 
#> #pvxtxlbnsl .gt_col_headings {
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#> }
#> 
#> #pvxtxlbnsl .gt_col_heading {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: normal;
#>   text-transform: inherit;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#>   vertical-align: bottom;
#>   padding-top: 5px;
#>   padding-bottom: 6px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   overflow-x: hidden;
#> }
#> 
#> #pvxtxlbnsl .gt_column_spanner_outer {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: normal;
#>   text-transform: inherit;
#>   padding-top: 0;
#>   padding-bottom: 0;
#>   padding-left: 4px;
#>   padding-right: 4px;
#> }
#> 
#> #pvxtxlbnsl .gt_column_spanner_outer:first-child {
#>   padding-left: 0;
#> }
#> 
#> #pvxtxlbnsl .gt_column_spanner_outer:last-child {
#>   padding-right: 0;
#> }
#> 
#> #pvxtxlbnsl .gt_column_spanner {
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   vertical-align: bottom;
#>   padding-top: 5px;
#>   padding-bottom: 5px;
#>   overflow-x: hidden;
#>   display: inline-block;
#>   width: 100%;
#> }
#> 
#> #pvxtxlbnsl .gt_spanner_row {
#>   border-bottom-style: hidden;
#> }
#> 
#> #pvxtxlbnsl .gt_group_heading {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: initial;
#>   text-transform: inherit;
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#>   vertical-align: middle;
#>   text-align: left;
#> }
#> 
#> #pvxtxlbnsl .gt_empty_group_heading {
#>   padding: 0.5px;
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: initial;
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   vertical-align: middle;
#> }
#> 
#> #pvxtxlbnsl .gt_from_md > :first-child {
#>   margin-top: 0;
#> }
#> 
#> #pvxtxlbnsl .gt_from_md > :last-child {
#>   margin-bottom: 0;
#> }
#> 
#> #pvxtxlbnsl .gt_row {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   margin: 10px;
#>   border-top-style: solid;
#>   border-top-width: 1px;
#>   border-top-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#>   vertical-align: middle;
#>   overflow-x: hidden;
#> }
#> 
#> #pvxtxlbnsl .gt_stub {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: initial;
#>   text-transform: inherit;
#>   border-right-style: solid;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #pvxtxlbnsl .gt_stub_row_group {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: initial;
#>   text-transform: inherit;
#>   border-right-style: solid;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   vertical-align: top;
#> }
#> 
#> #pvxtxlbnsl .gt_row_group_first td {
#>   border-top-width: 2px;
#> }
#> 
#> #pvxtxlbnsl .gt_row_group_first th {
#>   border-top-width: 2px;
#> }
#> 
#> #pvxtxlbnsl .gt_summary_row {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   text-transform: inherit;
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #pvxtxlbnsl .gt_first_summary_row {
#>   border-top-style: solid;
#>   border-top-color: #D3D3D3;
#> }
#> 
#> #pvxtxlbnsl .gt_first_summary_row.thick {
#>   border-top-width: 2px;
#> }
#> 
#> #pvxtxlbnsl .gt_last_summary_row {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#> }
#> 
#> #pvxtxlbnsl .gt_grand_summary_row {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   text-transform: inherit;
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #pvxtxlbnsl .gt_first_grand_summary_row {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-top-style: double;
#>   border-top-width: 6px;
#>   border-top-color: #D3D3D3;
#> }
#> 
#> #pvxtxlbnsl .gt_last_grand_summary_row_top {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-bottom-style: double;
#>   border-bottom-width: 6px;
#>   border-bottom-color: #D3D3D3;
#> }
#> 
#> #pvxtxlbnsl .gt_striped {
#>   background-color: rgba(128, 128, 128, 0.05);
#> }
#> 
#> #pvxtxlbnsl .gt_table_body {
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#> }
#> 
#> #pvxtxlbnsl .gt_footnotes {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   border-bottom-style: none;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 2px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#> }
#> 
#> #pvxtxlbnsl .gt_footnote {
#>   margin: 0px;
#>   font-size: 90%;
#>   padding-top: 4px;
#>   padding-bottom: 4px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #pvxtxlbnsl .gt_sourcenotes {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   border-bottom-style: none;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 2px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#> }
#> 
#> #pvxtxlbnsl .gt_sourcenote {
#>   font-size: 90%;
#>   padding-top: 4px;
#>   padding-bottom: 4px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #pvxtxlbnsl .gt_left {
#>   text-align: left;
#> }
#> 
#> #pvxtxlbnsl .gt_center {
#>   text-align: center;
#> }
#> 
#> #pvxtxlbnsl .gt_right {
#>   text-align: right;
#>   font-variant-numeric: tabular-nums;
#> }
#> 
#> #pvxtxlbnsl .gt_font_normal {
#>   font-weight: normal;
#> }
#> 
#> #pvxtxlbnsl .gt_font_bold {
#>   font-weight: bold;
#> }
#> 
#> #pvxtxlbnsl .gt_font_italic {
#>   font-style: italic;
#> }
#> 
#> #pvxtxlbnsl .gt_super {
#>   font-size: 65%;
#> }
#> 
#> #pvxtxlbnsl .gt_footnote_marks {
#>   font-size: 75%;
#>   vertical-align: 0.4em;
#>   position: initial;
#> }
#> 
#> #pvxtxlbnsl .gt_asterisk {
#>   font-size: 100%;
#>   vertical-align: 0;
#> }
#> 
#> #pvxtxlbnsl .gt_indent_1 {
#>   text-indent: 5px;
#> }
#> 
#> #pvxtxlbnsl .gt_indent_2 {
#>   text-indent: 10px;
#> }
#> 
#> #pvxtxlbnsl .gt_indent_3 {
#>   text-indent: 15px;
#> }
#> 
#> #pvxtxlbnsl .gt_indent_4 {
#>   text-indent: 20px;
#> }
#> 
#> #pvxtxlbnsl .gt_indent_5 {
#>   text-indent: 25px;
#> }
#> 
#> #pvxtxlbnsl .katex-display {
#>   display: inline-flex !important;
#>   margin-bottom: 0.75em !important;
#> }
#> 
#> #pvxtxlbnsl div.Reactable > div.rt-table > div.rt-thead > div.rt-tr.rt-tr-group-header > div.rt-th-group:after {
#>   height: 0px !important;
#> }
#> </style>
#>   <table class="gt_table" data-quarto-disable-processing="false" data-quarto-bootstrap="false">
#>   <thead>
#>     <tr class="gt_col_headings">
#>       <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="label"><span class='gt_from_md'><strong>Characteristic</strong></span></th>
#>       <th class="gt_col_heading gt_columns_bottom_border gt_center" rowspan="1" colspan="1" scope="col" id="stat_2"><span class='gt_from_md'><strong>Drug B</strong><br />
#> N = 102</span><span class="gt_footnote_marks" style="white-space:nowrap;font-style:italic;font-weight:normal;line-height:0;"><sup>1</sup></span></th>
#>     </tr>
#>   </thead>
#>   <tbody class="gt_table_body">
#>     <tr><td headers="label" class="gt_row gt_left">Patient Died</td>
#> <td headers="stat_2" class="gt_row gt_center">60 (59%)</td></tr>
#>     <tr><td headers="label" class="gt_row gt_left">Months to Death/Censor</td>
#> <td headers="stat_2" class="gt_row gt_center">21.2 (14.5, 24.0)</td></tr>
#>   </tbody>
#>   
#>   <tfoot class="gt_footnotes">
#>     <tr>
#>       <td class="gt_footnote" colspan="2"><span class="gt_footnote_marks" style="white-space:nowrap;font-style:italic;font-weight:normal;line-height:0;"><sup>1</sup></span> <span class='gt_from_md'>n (%); Median (Q1, Q3)</span></td>
#>     </tr>
#>   </tfoot>
#> </table>
#> </div>
#> 

# Example 4 ----------------------------------
# Both row and column splitting
trial |>
  tbl_summary(by = trt) |>
  tbl_split_by_rows(variables = c(marker, grade)) |>
  tbl_split_by_columns(groups = list("stat_1", "stat_2")) |>
  tail(n = 1) # Print only last table for simplicity
#> [[1]]
#> <div id="jrzvnbmmzk" style="padding-left:0px;padding-right:0px;padding-top:10px;padding-bottom:10px;overflow-x:auto;overflow-y:auto;width:auto;height:auto;">
#>   <style>#jrzvnbmmzk table {
#>   font-family: system-ui, 'Segoe UI', Roboto, Helvetica, Arial, sans-serif, 'Apple Color Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol', 'Noto Color Emoji';
#>   -webkit-font-smoothing: antialiased;
#>   -moz-osx-font-smoothing: grayscale;
#> }
#> 
#> #jrzvnbmmzk thead, #jrzvnbmmzk tbody, #jrzvnbmmzk tfoot, #jrzvnbmmzk tr, #jrzvnbmmzk td, #jrzvnbmmzk th {
#>   border-style: none;
#> }
#> 
#> #jrzvnbmmzk p {
#>   margin: 0;
#>   padding: 0;
#> }
#> 
#> #jrzvnbmmzk .gt_table {
#>   display: table;
#>   border-collapse: collapse;
#>   line-height: normal;
#>   margin-left: auto;
#>   margin-right: auto;
#>   color: #333333;
#>   font-size: 16px;
#>   font-weight: normal;
#>   font-style: normal;
#>   background-color: #FFFFFF;
#>   width: auto;
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #A8A8A8;
#>   border-right-style: none;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #A8A8A8;
#>   border-left-style: none;
#>   border-left-width: 2px;
#>   border-left-color: #D3D3D3;
#> }
#> 
#> #jrzvnbmmzk .gt_caption {
#>   padding-top: 4px;
#>   padding-bottom: 4px;
#> }
#> 
#> #jrzvnbmmzk .gt_title {
#>   color: #333333;
#>   font-size: 125%;
#>   font-weight: initial;
#>   padding-top: 4px;
#>   padding-bottom: 4px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-bottom-color: #FFFFFF;
#>   border-bottom-width: 0;
#> }
#> 
#> #jrzvnbmmzk .gt_subtitle {
#>   color: #333333;
#>   font-size: 85%;
#>   font-weight: initial;
#>   padding-top: 3px;
#>   padding-bottom: 5px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-top-color: #FFFFFF;
#>   border-top-width: 0;
#> }
#> 
#> #jrzvnbmmzk .gt_heading {
#>   background-color: #FFFFFF;
#>   text-align: center;
#>   border-bottom-color: #FFFFFF;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#> }
#> 
#> #jrzvnbmmzk .gt_bottom_border {
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#> }
#> 
#> #jrzvnbmmzk .gt_col_headings {
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#> }
#> 
#> #jrzvnbmmzk .gt_col_heading {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: normal;
#>   text-transform: inherit;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#>   vertical-align: bottom;
#>   padding-top: 5px;
#>   padding-bottom: 6px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   overflow-x: hidden;
#> }
#> 
#> #jrzvnbmmzk .gt_column_spanner_outer {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: normal;
#>   text-transform: inherit;
#>   padding-top: 0;
#>   padding-bottom: 0;
#>   padding-left: 4px;
#>   padding-right: 4px;
#> }
#> 
#> #jrzvnbmmzk .gt_column_spanner_outer:first-child {
#>   padding-left: 0;
#> }
#> 
#> #jrzvnbmmzk .gt_column_spanner_outer:last-child {
#>   padding-right: 0;
#> }
#> 
#> #jrzvnbmmzk .gt_column_spanner {
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   vertical-align: bottom;
#>   padding-top: 5px;
#>   padding-bottom: 5px;
#>   overflow-x: hidden;
#>   display: inline-block;
#>   width: 100%;
#> }
#> 
#> #jrzvnbmmzk .gt_spanner_row {
#>   border-bottom-style: hidden;
#> }
#> 
#> #jrzvnbmmzk .gt_group_heading {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: initial;
#>   text-transform: inherit;
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#>   vertical-align: middle;
#>   text-align: left;
#> }
#> 
#> #jrzvnbmmzk .gt_empty_group_heading {
#>   padding: 0.5px;
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: initial;
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   vertical-align: middle;
#> }
#> 
#> #jrzvnbmmzk .gt_from_md > :first-child {
#>   margin-top: 0;
#> }
#> 
#> #jrzvnbmmzk .gt_from_md > :last-child {
#>   margin-bottom: 0;
#> }
#> 
#> #jrzvnbmmzk .gt_row {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   margin: 10px;
#>   border-top-style: solid;
#>   border-top-width: 1px;
#>   border-top-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#>   vertical-align: middle;
#>   overflow-x: hidden;
#> }
#> 
#> #jrzvnbmmzk .gt_stub {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: initial;
#>   text-transform: inherit;
#>   border-right-style: solid;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #jrzvnbmmzk .gt_stub_row_group {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: initial;
#>   text-transform: inherit;
#>   border-right-style: solid;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   vertical-align: top;
#> }
#> 
#> #jrzvnbmmzk .gt_row_group_first td {
#>   border-top-width: 2px;
#> }
#> 
#> #jrzvnbmmzk .gt_row_group_first th {
#>   border-top-width: 2px;
#> }
#> 
#> #jrzvnbmmzk .gt_summary_row {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   text-transform: inherit;
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #jrzvnbmmzk .gt_first_summary_row {
#>   border-top-style: solid;
#>   border-top-color: #D3D3D3;
#> }
#> 
#> #jrzvnbmmzk .gt_first_summary_row.thick {
#>   border-top-width: 2px;
#> }
#> 
#> #jrzvnbmmzk .gt_last_summary_row {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#> }
#> 
#> #jrzvnbmmzk .gt_grand_summary_row {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   text-transform: inherit;
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #jrzvnbmmzk .gt_first_grand_summary_row {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-top-style: double;
#>   border-top-width: 6px;
#>   border-top-color: #D3D3D3;
#> }
#> 
#> #jrzvnbmmzk .gt_last_grand_summary_row_top {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-bottom-style: double;
#>   border-bottom-width: 6px;
#>   border-bottom-color: #D3D3D3;
#> }
#> 
#> #jrzvnbmmzk .gt_striped {
#>   background-color: rgba(128, 128, 128, 0.05);
#> }
#> 
#> #jrzvnbmmzk .gt_table_body {
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#> }
#> 
#> #jrzvnbmmzk .gt_footnotes {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   border-bottom-style: none;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 2px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#> }
#> 
#> #jrzvnbmmzk .gt_footnote {
#>   margin: 0px;
#>   font-size: 90%;
#>   padding-top: 4px;
#>   padding-bottom: 4px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #jrzvnbmmzk .gt_sourcenotes {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   border-bottom-style: none;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 2px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#> }
#> 
#> #jrzvnbmmzk .gt_sourcenote {
#>   font-size: 90%;
#>   padding-top: 4px;
#>   padding-bottom: 4px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #jrzvnbmmzk .gt_left {
#>   text-align: left;
#> }
#> 
#> #jrzvnbmmzk .gt_center {
#>   text-align: center;
#> }
#> 
#> #jrzvnbmmzk .gt_right {
#>   text-align: right;
#>   font-variant-numeric: tabular-nums;
#> }
#> 
#> #jrzvnbmmzk .gt_font_normal {
#>   font-weight: normal;
#> }
#> 
#> #jrzvnbmmzk .gt_font_bold {
#>   font-weight: bold;
#> }
#> 
#> #jrzvnbmmzk .gt_font_italic {
#>   font-style: italic;
#> }
#> 
#> #jrzvnbmmzk .gt_super {
#>   font-size: 65%;
#> }
#> 
#> #jrzvnbmmzk .gt_footnote_marks {
#>   font-size: 75%;
#>   vertical-align: 0.4em;
#>   position: initial;
#> }
#> 
#> #jrzvnbmmzk .gt_asterisk {
#>   font-size: 100%;
#>   vertical-align: 0;
#> }
#> 
#> #jrzvnbmmzk .gt_indent_1 {
#>   text-indent: 5px;
#> }
#> 
#> #jrzvnbmmzk .gt_indent_2 {
#>   text-indent: 10px;
#> }
#> 
#> #jrzvnbmmzk .gt_indent_3 {
#>   text-indent: 15px;
#> }
#> 
#> #jrzvnbmmzk .gt_indent_4 {
#>   text-indent: 20px;
#> }
#> 
#> #jrzvnbmmzk .gt_indent_5 {
#>   text-indent: 25px;
#> }
#> 
#> #jrzvnbmmzk .katex-display {
#>   display: inline-flex !important;
#>   margin-bottom: 0.75em !important;
#> }
#> 
#> #jrzvnbmmzk div.Reactable > div.rt-table > div.rt-thead > div.rt-tr.rt-tr-group-header > div.rt-th-group:after {
#>   height: 0px !important;
#> }
#> </style>
#>   <table class="gt_table" data-quarto-disable-processing="false" data-quarto-bootstrap="false">
#>   <thead>
#>     <tr class="gt_col_headings">
#>       <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="label"><span class='gt_from_md'><strong>Characteristic</strong></span></th>
#>       <th class="gt_col_heading gt_columns_bottom_border gt_center" rowspan="1" colspan="1" scope="col" id="stat_2"><span class='gt_from_md'><strong>Drug B</strong><br />
#> N = 102</span><span class="gt_footnote_marks" style="white-space:nowrap;font-style:italic;font-weight:normal;line-height:0;"><sup>1</sup></span></th>
#>     </tr>
#>   </thead>
#>   <tbody class="gt_table_body">
#>     <tr><td headers="label" class="gt_row gt_left">Tumor Response</td>
#> <td headers="stat_2" class="gt_row gt_center">33 (34%)</td></tr>
#>     <tr><td headers="label" class="gt_row gt_left">    Unknown</td>
#> <td headers="stat_2" class="gt_row gt_center">4</td></tr>
#>     <tr><td headers="label" class="gt_row gt_left">Patient Died</td>
#> <td headers="stat_2" class="gt_row gt_center">60 (59%)</td></tr>
#>     <tr><td headers="label" class="gt_row gt_left">Months to Death/Censor</td>
#> <td headers="stat_2" class="gt_row gt_center">21.2 (14.5, 24.0)</td></tr>
#>   </tbody>
#>   
#>   <tfoot class="gt_footnotes">
#>     <tr>
#>       <td class="gt_footnote" colspan="2"><span class="gt_footnote_marks" style="white-space:nowrap;font-style:italic;font-weight:normal;line-height:0;"><sup>1</sup></span> <span class='gt_from_md'>Median (Q1, Q3); n (%)</span></td>
#>     </tr>
#>   </tfoot>
#> </table>
#> </div>
#> 

# Example 5 ------------------------------
# Split by rows with footnotes and caption
trial |>
  tbl_summary(by = trt, missing = "no") |>
  modify_footnote_header(
    footnote = "All but four subjects received both treatments in a crossover design",
    columns = all_stat_cols(),
    replace = FALSE
  ) |>
  modify_footnote_body(
    footnote = "Tumor grade was assessed _before_ treatment began",
    columns = "label",
    rows = variable == "grade" & row_type == "label"
  ) |>
  modify_spanning_header(
    c(stat_1, stat_2) ~ "**TRT**"
  ) |>
  modify_abbreviation("I = 1, II = 2, III = 3") |>
  modify_caption("_Some caption_") |>
  modify_footnote_spanning_header(
    footnote = "Treatment",
    columns = c(stat_1)
  ) |>
  modify_source_note("Some source note!") |>
  tbl_split_by_rows(variables = c(marker, stage, grade), footnotes = "last", caption = "first") |>
  tail(n = 2) |>
  head(n = 1) # Print only one but not last table for simplicity
#> [[1]]
#> <div id="avcriyjkom" style="padding-left:0px;padding-right:0px;padding-top:10px;padding-bottom:10px;overflow-x:auto;overflow-y:auto;width:auto;height:auto;">
#>   <style>#avcriyjkom table {
#>   font-family: system-ui, 'Segoe UI', Roboto, Helvetica, Arial, sans-serif, 'Apple Color Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol', 'Noto Color Emoji';
#>   -webkit-font-smoothing: antialiased;
#>   -moz-osx-font-smoothing: grayscale;
#> }
#> 
#> #avcriyjkom thead, #avcriyjkom tbody, #avcriyjkom tfoot, #avcriyjkom tr, #avcriyjkom td, #avcriyjkom th {
#>   border-style: none;
#> }
#> 
#> #avcriyjkom p {
#>   margin: 0;
#>   padding: 0;
#> }
#> 
#> #avcriyjkom .gt_table {
#>   display: table;
#>   border-collapse: collapse;
#>   line-height: normal;
#>   margin-left: auto;
#>   margin-right: auto;
#>   color: #333333;
#>   font-size: 16px;
#>   font-weight: normal;
#>   font-style: normal;
#>   background-color: #FFFFFF;
#>   width: auto;
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #A8A8A8;
#>   border-right-style: none;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #A8A8A8;
#>   border-left-style: none;
#>   border-left-width: 2px;
#>   border-left-color: #D3D3D3;
#> }
#> 
#> #avcriyjkom .gt_caption {
#>   padding-top: 4px;
#>   padding-bottom: 4px;
#> }
#> 
#> #avcriyjkom .gt_title {
#>   color: #333333;
#>   font-size: 125%;
#>   font-weight: initial;
#>   padding-top: 4px;
#>   padding-bottom: 4px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-bottom-color: #FFFFFF;
#>   border-bottom-width: 0;
#> }
#> 
#> #avcriyjkom .gt_subtitle {
#>   color: #333333;
#>   font-size: 85%;
#>   font-weight: initial;
#>   padding-top: 3px;
#>   padding-bottom: 5px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-top-color: #FFFFFF;
#>   border-top-width: 0;
#> }
#> 
#> #avcriyjkom .gt_heading {
#>   background-color: #FFFFFF;
#>   text-align: center;
#>   border-bottom-color: #FFFFFF;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#> }
#> 
#> #avcriyjkom .gt_bottom_border {
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#> }
#> 
#> #avcriyjkom .gt_col_headings {
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#> }
#> 
#> #avcriyjkom .gt_col_heading {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: normal;
#>   text-transform: inherit;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#>   vertical-align: bottom;
#>   padding-top: 5px;
#>   padding-bottom: 6px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   overflow-x: hidden;
#> }
#> 
#> #avcriyjkom .gt_column_spanner_outer {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: normal;
#>   text-transform: inherit;
#>   padding-top: 0;
#>   padding-bottom: 0;
#>   padding-left: 4px;
#>   padding-right: 4px;
#> }
#> 
#> #avcriyjkom .gt_column_spanner_outer:first-child {
#>   padding-left: 0;
#> }
#> 
#> #avcriyjkom .gt_column_spanner_outer:last-child {
#>   padding-right: 0;
#> }
#> 
#> #avcriyjkom .gt_column_spanner {
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   vertical-align: bottom;
#>   padding-top: 5px;
#>   padding-bottom: 5px;
#>   overflow-x: hidden;
#>   display: inline-block;
#>   width: 100%;
#> }
#> 
#> #avcriyjkom .gt_spanner_row {
#>   border-bottom-style: hidden;
#> }
#> 
#> #avcriyjkom .gt_group_heading {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: initial;
#>   text-transform: inherit;
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#>   vertical-align: middle;
#>   text-align: left;
#> }
#> 
#> #avcriyjkom .gt_empty_group_heading {
#>   padding: 0.5px;
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: initial;
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   vertical-align: middle;
#> }
#> 
#> #avcriyjkom .gt_from_md > :first-child {
#>   margin-top: 0;
#> }
#> 
#> #avcriyjkom .gt_from_md > :last-child {
#>   margin-bottom: 0;
#> }
#> 
#> #avcriyjkom .gt_row {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   margin: 10px;
#>   border-top-style: solid;
#>   border-top-width: 1px;
#>   border-top-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 1px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 1px;
#>   border-right-color: #D3D3D3;
#>   vertical-align: middle;
#>   overflow-x: hidden;
#> }
#> 
#> #avcriyjkom .gt_stub {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: initial;
#>   text-transform: inherit;
#>   border-right-style: solid;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #avcriyjkom .gt_stub_row_group {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   font-size: 100%;
#>   font-weight: initial;
#>   text-transform: inherit;
#>   border-right-style: solid;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   vertical-align: top;
#> }
#> 
#> #avcriyjkom .gt_row_group_first td {
#>   border-top-width: 2px;
#> }
#> 
#> #avcriyjkom .gt_row_group_first th {
#>   border-top-width: 2px;
#> }
#> 
#> #avcriyjkom .gt_summary_row {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   text-transform: inherit;
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #avcriyjkom .gt_first_summary_row {
#>   border-top-style: solid;
#>   border-top-color: #D3D3D3;
#> }
#> 
#> #avcriyjkom .gt_first_summary_row.thick {
#>   border-top-width: 2px;
#> }
#> 
#> #avcriyjkom .gt_last_summary_row {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#> }
#> 
#> #avcriyjkom .gt_grand_summary_row {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   text-transform: inherit;
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #avcriyjkom .gt_first_grand_summary_row {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-top-style: double;
#>   border-top-width: 6px;
#>   border-top-color: #D3D3D3;
#> }
#> 
#> #avcriyjkom .gt_last_grand_summary_row_top {
#>   padding-top: 8px;
#>   padding-bottom: 8px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#>   border-bottom-style: double;
#>   border-bottom-width: 6px;
#>   border-bottom-color: #D3D3D3;
#> }
#> 
#> #avcriyjkom .gt_striped {
#>   background-color: rgba(128, 128, 128, 0.05);
#> }
#> 
#> #avcriyjkom .gt_table_body {
#>   border-top-style: solid;
#>   border-top-width: 2px;
#>   border-top-color: #D3D3D3;
#>   border-bottom-style: solid;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#> }
#> 
#> #avcriyjkom .gt_footnotes {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   border-bottom-style: none;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 2px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#> }
#> 
#> #avcriyjkom .gt_footnote {
#>   margin: 0px;
#>   font-size: 90%;
#>   padding-top: 4px;
#>   padding-bottom: 4px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #avcriyjkom .gt_sourcenotes {
#>   color: #333333;
#>   background-color: #FFFFFF;
#>   border-bottom-style: none;
#>   border-bottom-width: 2px;
#>   border-bottom-color: #D3D3D3;
#>   border-left-style: none;
#>   border-left-width: 2px;
#>   border-left-color: #D3D3D3;
#>   border-right-style: none;
#>   border-right-width: 2px;
#>   border-right-color: #D3D3D3;
#> }
#> 
#> #avcriyjkom .gt_sourcenote {
#>   font-size: 90%;
#>   padding-top: 4px;
#>   padding-bottom: 4px;
#>   padding-left: 5px;
#>   padding-right: 5px;
#> }
#> 
#> #avcriyjkom .gt_left {
#>   text-align: left;
#> }
#> 
#> #avcriyjkom .gt_center {
#>   text-align: center;
#> }
#> 
#> #avcriyjkom .gt_right {
#>   text-align: right;
#>   font-variant-numeric: tabular-nums;
#> }
#> 
#> #avcriyjkom .gt_font_normal {
#>   font-weight: normal;
#> }
#> 
#> #avcriyjkom .gt_font_bold {
#>   font-weight: bold;
#> }
#> 
#> #avcriyjkom .gt_font_italic {
#>   font-style: italic;
#> }
#> 
#> #avcriyjkom .gt_super {
#>   font-size: 65%;
#> }
#> 
#> #avcriyjkom .gt_footnote_marks {
#>   font-size: 75%;
#>   vertical-align: 0.4em;
#>   position: initial;
#> }
#> 
#> #avcriyjkom .gt_asterisk {
#>   font-size: 100%;
#>   vertical-align: 0;
#> }
#> 
#> #avcriyjkom .gt_indent_1 {
#>   text-indent: 5px;
#> }
#> 
#> #avcriyjkom .gt_indent_2 {
#>   text-indent: 10px;
#> }
#> 
#> #avcriyjkom .gt_indent_3 {
#>   text-indent: 15px;
#> }
#> 
#> #avcriyjkom .gt_indent_4 {
#>   text-indent: 20px;
#> }
#> 
#> #avcriyjkom .gt_indent_5 {
#>   text-indent: 25px;
#> }
#> 
#> #avcriyjkom .katex-display {
#>   display: inline-flex !important;
#>   margin-bottom: 0.75em !important;
#> }
#> 
#> #avcriyjkom div.Reactable > div.rt-table > div.rt-thead > div.rt-tr.rt-tr-group-header > div.rt-th-group:after {
#>   height: 0px !important;
#> }
#> </style>
#>   <table class="gt_table" data-quarto-disable-processing="false" data-quarto-bootstrap="false">
#>   <thead>
#>     <tr class="gt_col_headings gt_spanner_row">
#>       <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="2" colspan="1" scope="col" id="label"><span class='gt_from_md'><strong>Characteristic</strong></span></th>
#>       <th class="gt_center gt_columns_top_border gt_column_spanner_outer" rowspan="1" colspan="2" scope="colgroup" id="level 1; stat_1">
#>         <div class="gt_column_spanner"><span class='gt_from_md'><strong>TRT</strong></span><span class="gt_footnote_marks" style="white-space:nowrap;font-style:italic;font-weight:normal;line-height:0;"><sup>1</sup></span></div>
#>       </th>
#>     </tr>
#>     <tr class="gt_col_headings">
#>       <th class="gt_col_heading gt_columns_bottom_border gt_center" rowspan="1" colspan="1" scope="col" id="stat_1"><span class='gt_from_md'><strong>Drug A</strong><br />
#> N = 98</span><span class="gt_footnote_marks" style="white-space:nowrap;font-style:italic;font-weight:normal;line-height:0;"><sup>2,3</sup></span></th>
#>       <th class="gt_col_heading gt_columns_bottom_border gt_center" rowspan="1" colspan="1" scope="col" id="stat_2"><span class='gt_from_md'><strong>Drug B</strong><br />
#> N = 102</span><span class="gt_footnote_marks" style="white-space:nowrap;font-style:italic;font-weight:normal;line-height:0;"><sup>2,3</sup></span></th>
#>     </tr>
#>   </thead>
#>   <tbody class="gt_table_body">
#>     <tr><td headers="label" class="gt_row gt_left">Grade<span class="gt_footnote_marks" style="white-space:nowrap;font-style:italic;font-weight:normal;line-height:0;"><sup>4</sup></span></td>
#> <td headers="stat_1" class="gt_row gt_center"><br /></td>
#> <td headers="stat_2" class="gt_row gt_center"><br /></td></tr>
#>     <tr><td headers="label" class="gt_row gt_left">    I</td>
#> <td headers="stat_1" class="gt_row gt_center">35 (36%)</td>
#> <td headers="stat_2" class="gt_row gt_center">33 (32%)</td></tr>
#>     <tr><td headers="label" class="gt_row gt_left">    II</td>
#> <td headers="stat_1" class="gt_row gt_center">32 (33%)</td>
#> <td headers="stat_2" class="gt_row gt_center">36 (35%)</td></tr>
#>     <tr><td headers="label" class="gt_row gt_left">    III</td>
#> <td headers="stat_1" class="gt_row gt_center">31 (32%)</td>
#> <td headers="stat_2" class="gt_row gt_center">33 (32%)</td></tr>
#>   </tbody>
#>   
#>   <tfoot class="gt_footnotes">
#>     <tr>
#>       <td class="gt_footnote" colspan="3"><span class="gt_footnote_marks" style="white-space:nowrap;font-style:italic;font-weight:normal;line-height:0;"><sup>1</sup></span> <span class='gt_from_md'>Treatment</span></td>
#>     </tr>
#>     <tr>
#>       <td class="gt_footnote" colspan="3"><span class="gt_footnote_marks" style="white-space:nowrap;font-style:italic;font-weight:normal;line-height:0;"><sup>2</sup></span> <span class='gt_from_md'>Median (Q1, Q3); n (%)</span></td>
#>     </tr>
#>     <tr>
#>       <td class="gt_footnote" colspan="3"><span class="gt_footnote_marks" style="white-space:nowrap;font-style:italic;font-weight:normal;line-height:0;"><sup>3</sup></span> <span class='gt_from_md'>All but four subjects received both treatments in a crossover design</span></td>
#>     </tr>
#>     <tr>
#>       <td class="gt_footnote" colspan="3"><span class="gt_footnote_marks" style="white-space:nowrap;font-style:italic;font-weight:normal;line-height:0;"><sup>4</sup></span> <span class='gt_from_md'>Tumor grade was assessed <em>before</em> treatment began</span></td>
#>     </tr>
#>   </tfoot>
#> </table>
#> </div>
#>